When combined with Adrenocortical hormone, especially Mineralocorticoid, it can increase the risk of edema. Combined use of Adrenocorticotropic hormone or glucocorticoid can accelerate the production of acne. Androgen and protein Anabolic steroid can reduce the concentration of coagulation factor precursors (due to changes in the synthesis and decomposition of coagulation factor precursors), and increase the affinity between anticoagulant substances and receptors, so they can enhance the anticoagulant activity. The dosage shall be reduced when combined with Dicoumarol or indanone derivatives. When combined with drugs with hepatotoxicity, it can exacerbate damage to the liver, especially for long-term use and patients with previous liver diseases.
With Barbital, Carbamazepine, methamphetamine, Phenylbutazone and rifampicin, estrogen activity will be reduced.