Dehydroepiandrosterone

Chemical Name: Dehydroepiandrosterone

CAS Number: 53-43-0

Main Benefits: Boosts Energy by Increasing the Level Adrenaline-Hormone.

Application: dietary supplements

Dehydroepiandrosterone is a naturally occurring hormone in the human body, synthesized and released from adrenal glands, gonads, and the brain. The brain and these glands synthesize this precursor hormone to increase the levels of androgens and estrogen in the body.

Dehydroepiandrosterone is the most abundant steroid precursor in the human body and a decrease in its levels in the body is indicative of severe adrenal insufficiency. DHEA levels are frequently used in the medical field as a biomarker for the analysis of the function and health of adrenal glands and pituitary glands. This is because almost all of DHEA in the human body is synthesized from the adrenal gland. Due to the importance of the levels of the hormone and the physiological difference of levels amongst different genders and age groups, doctors have to thoroughly follow up and check them regularly to ensure proper health.

The body produces dehydroepiandrosterone in the adrenal glands, testes, ovaries, and brain. However, most dehydroepiandrosterone synthesis occurs in the adrenals due to the amount of CYP17 enzymes expressed there. DHEA is a critical endogenous precursor to produce the sex hormones androgen, dihydrotestosterone (DHT), and estrogen. However, it performs several other biological functions by interacting with nuclear, cell surface, and neurotrophic factor receptors in the brain.

Low Dehydroepiandrosterone levels can have negative effects on heart health and emotional wellbeing. It also increases the risk of mortality. Keeping DHEA levels elevated isn't only a concern for older adults either. By 30, DHEA levels begin to plummet. Over time, levels decrease by up to 80%.

DHEA's most potent effect is reducing several negative aspects of aging. Several studies conducted on men taking DHEA noted improvements in mood, heart health, hip bone density, joint health, and more. In women, DHEA supplements showed improvements in mood, menopause symptoms, sexuality, heart health, and bone density.

Dehydroepiandrosterone supplements may improve strength and exercise performance in certain individuals. Studies on older adults found DHEA improved their strength and physical functions. These improvements may help prevent falls and the associated bone fractures in the elderly. DHEA supplements may also enhance lean muscle mass in individuals with inhibited or impaired adrenal functions.

Dehydroepiandrosterone supplements may improve fat mass by influencing food intake. Animal studies have shown that DHEA reduced how much food the subjects consumed with a notable reduction in fatty foods. In humans, DHEA supplements help improve feelings of satiety after eating.

Dehydroepiandrosterone powder has several uses and most of these uses are the same as those of endogenous DHEA. Naturally occurring DHEA has different functions in the human body, such as those mentioned below:

• Synthesis of Testosterone and Dihydrotestosterone (DHT)
• Synthesis of Estrogen
• Inhibition of G6PDH to lower NADPH induced free radical formation
• Binding to neurotrophin receptors to reduce the incidence of neurodegenerative diseases
• Agonist, negative allosteric modulator, and a positive allosteric modulator of different neurotransmitters
• Antiglucocorticoid effects
• These are the main functions of DHEA with a couple of them only being discovered recently. DHEA powder is believed to have the same uses and some more as well, as the uses of DHEA itself are still being studied and not all are yet known.

While several scientific studies and researches were performed to study the efficacy and benefits of the hormone, these studies also helped determine the appropriate dosage of Dehydroepiandrosterone powder and supplements. The well-tolerated and generally safe dosage of dehydroepiandrosterone powder lies between the 25mg and 50 mg range. However, dosages of up to 500mg are considered to be safe and the lowest effective dose is considered to be 10mg.

A specific study type showed that 25mg of Dehydroepiandrosterone powder can be consumed every day, for up to two years and 50mg can be consumed every day for up to a year, without any reported toxicities and/or overdose.

Dehydroepiandrosterone powder is considered to be relatively safe with no toxicities or severe adverse effects being reported yet. However, this hormonal supplement can interact with certain medications and produce adverse effects, hence why these interactions should be avoided. Moreover, the use of Dehydroepiandrosterone powder is strictly contraindicated in patients with cancer, especially those that are effect by the sex hormone levels in the body.

Mild adverse effects of the product include acne, oily skin, and excessive hair growth in the armpits and the groin region. These side effects are self-limited and almost always resolve spontaneously, without any medical intervention.

Features

• It has the effect of maintaining the ovaries, can promote the development of female follicles, and improve the quality of follicles;
• It can regulate the endocrine function of the ovary, prevent and improve endocrine dysfunction;
• It can promote women's ovulation, which has a certain effect on improving women's fertility;
• It can improve physical fitness, strengthen disease resistance, and improve sleep. Regulate bad emotions;
• It can improve the quality of female sexual life and increase sexual pleasure;

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