DHT

DHT DETAIL INFORMATION

 

Product Name: Stanolone

Synonyms: DHT; Dihydrotestosterone

CAS: 521-18-6

MF: C19H30O2

MW: 290.45

EINECS: 208-307-3

Product Categories: Steroid and Hormone

Mol File: 521-18-6.mol

Stanolone Chemical Properties

 

Melting point: 178-183 °C

Alpha: 27 º

Boiling point: 372.52°C (rough estimate)

Density: 1.0320 (rough estimate)

Refractive index: 1.4709 (estimate)

Fp: 9℃

Storage temp.: 2-8°C

Solubility: Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml

Pka: 15.08±0.60(Predicted)

Water Solubility: 344.3g/L (temperature not stated)

Form: White Fine Powder

Dihydrotestosterone, a hormone with powerful androgenic actions, causes the body to mature during puberty and is responsible for many of the physical characteristics associated with adult males.

DHT plays a vital role in the sexual development of males. During embryonic life, DHT is involved primarily in the sexual differentiation of organs. Through adolescence and adulthood, DHT promotes prostate growth, sebaceous gland activity, male pattern baldness, and body, facial, and pubic hair growth.

Dihydrotestosterone is a hormone that stimulates the development of male characteristics (an androgen). It is made through conversion of the more commonly known androgen, testosterone. Almost 10% of the testosterone produced by an adult each day is converted to dihydrotestosterone. This takes place in the testes and prostate (in men), in the ovaries (in women), as well as the skin and other parts of the body such as the liver. This figure is much lower before puberty however, and it is thought that the increased dihydrotestosterone production may be responsible for the start of puberty in boys, causing development of the genitals (penis, testes and scrotum) and growth of pubic and body hair. This hormone also causes the prostate to grow and is thought to combine with testosterone causing the expression of male sexual behaviour. Dihydrotestosterone is many times more potent than testosterone, and many of the effects that testosterone has in the body only happen after it is converted to dihydrotestosterone.

Much less is known about the importance of dihydrotestosterone in women, but it is known to cause much of the body and pubic hair growth seen in girls after puberty and may help to determine the age at which girls begin puberty.

DHT directs the development of the external genitalia, including the penis and scrotum, and the prostate gland. During puberty, DHT plays an important role in the growth of facial and body hair, increased muscle mass, and deepening of the voice.1

Impact on Sexual Development

DHT has several effects on sexual development and sexual function, including:

• Pubic hair growth
• Facial hair growth
• Body hair growth

In particular, DHT plays an important role in the development of male external genitalia. At puberty, DHT is critical for penile growth. It works in combination with testosterone to increase the size of the male external genitalia.

This does not mean that taking testosterone or DHT will increase your penis size. Adult men who have completed puberty no longer have androgen receptors in their penile tissue.

Too much dihydrotestosterone, often resulting from excess testosterone production, has variable effects on men and women. It is unlikely that levels of dihydrotestosterone will be raised before the start of puberty. It is also unlikely that adult men with too much dihydrotestosterone would undergo recognisable changes. Women with too much dihydrotestosterone may develop increased body, facial and pubic hair growth (called hirsutism), stopping of menstrual periods (amenorrhoea) and increased acne. Abnormal changes to the genitalia may also occur in women with too much dihydrotestosterone.

Dihydrotestosterone is thought to have fewer effects in women and, as a result, it is believed they are relatively unaffected by having too little dihydrotestosterone. It is possible, however, that the start of puberty may be delayed in girls with too little dihydrotestosterone and the amount of pubic and body hair present in adult females may also be reduced.

In contrast, low levels of dihydrotestosterone in men can have dramatic effects. If there is too little dihydrotestosterone whilst male foetuses are still in the womb, for example, they may not be 'masculinised' and their genitalia may seem similar to that seen in girls of the same age. Later, boys with too little dihydrotestosterone may undergo some of the changes usually seen in puberty (such as muscle growth and production of sperm) but will not develop normal body hair growth and genital development.

DHT and testosterone are both classified as androgens. In the body, the enzyme 5-alpha reductase converts testosterone to DHT.

DHT is estimated to be around five times more powerful than testosterone. DHT is primarily created in the organs where it is used, such as the prostate.

Testosterone and DHT both bind to the same receptors. However, DHT does so more efficiently.

Most DHT and testosterone in the body are bound to proteins, such as albumin and sex hormone-binding globulin in the blood. With DHT, less than 1% of the hormone in the blood is circulating freely. This is slightly lower than the amount of free versus bound testosterone.

Albumin can bind a large amount of testosterone or other sex hormones but binds those hormones weakly. Sex hormone-binding globulin, in contrast, binds less hormone but does so more strongly.

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