Pramiracetam

Pramiracetam Basic Information

 

Product Name: Pramiracetam

CAS: 68497-62-1

MF: C14H27N3O2

MW: 269.38

EINECS: 806-175-7

Product Categories: Nootropic

Appearance: White to beige powder

Pramiracetam is a racetam molecule that was initially synthesized from piracetam due to its modifications having more anti-amnesiac potential in rats. Relative to the other racetams, pramiracetam is not that well researched but does appear to have some human evidence.

When looking at the animal evidence, otherwise healthy young and old rats seem to experience benefits to long-term memory formation with supplementation of pramiracetam. It appears to be effective when taken acutely (1-2 hours) before cognitive testing, and studies looking at working memory do not note much effects. Human studies support this, but they are limited in statistical power and currently there are no human studies in otherwise healthy youth for the purpose of cognitive enhancement.

The mechanisms of pramiracetam are not well known, but it appears to alter EEG activity in all tested rats (young and old) and may be able to enhance high-affinity choline uptake. It is similar to piracetam and other racetams in the sense that its mechanisms seem dependent on the adrenal glands and some peripheral effects, but beyond that the mechanisms have not been further elucidated.

Currently, the evidence using pramiracetam in humans uses either 400mg thrice daily or 600mg twice daily; both of these dosing regiments totals 1,200mg of pramiracetam daily.

It is unsure if pramiracetam should be taken with meals, and it is not clear if 1,200mg is the optimal dosage or not. This dose, however, does appear effective.

Pramiracetam helps boost acetylcholine (ACh) synthesis and use in your brain, and increases cerebral circulation. This compound is highly bioavailable, meaning it passes through the blood-brain barrier quite easily. As a nootropic, Pramiracetam easily crosses the blood-brain barrier.

And since it is fat-soluble, it must be taken with a healthy fat such as unrefined coconut oil or MCT Oil to ensure absorption.Pramiracetam increases the amount and efficiency of acetylcholine by influencing the high affinity choline uptake (HACU) system in your brain. This increase in ACh can have a profound effect on overall cognition and memory. With Pramiracetam, you'll find it easier to focus and learning ability will improve. This increase in ACh in your hippocampus helps with logic and understanding complex mathematical and technical subjects if that's your thing.

Increased neuroplasticity from more acetylcholine and improved cerebral circulation affects long-term potentiation. So you may find it easier to recall long-forgotten memories.

Researchers in Italy investigated Pramiracetam effects on memory, and memory training by a therapist. Types of memory measured were objective memory and metamemory performance.

Metamemory is both the inner-knowledge of one's own memories combined with the processes for formulating new memories with no inner-knowledge.

35 healthy volunteers were chosen with an average age of 64.8 years. 10 subjects received memory training only, 8 received Pramiracetam, 10 received both memory training and Pramiracetam, and the control group received nothing.

Results of the study showed that those receiving both memory training and Pramiracetam experienced a significant improvement in memory. Followed by the Pramiracetam group. The memory training-only group and control group scored the lowest.

The research team concluded that Pramiracetam significantly improves memory. And the addition of memory training to Pramiracetam has an even more profound effect of both types of memory measured.

Pramiracetam, a fat-soluble nootropic is known to enhance overall cognition, focus, long-term memory, and learning.

Unlike some other nootropics, Pramiracetam doesn't directly influence GABA, dopamine, norepinephrine, or serotonin in the brain, instead it increases nitric oxide activity which helps improve cerebral circulation.

Pramiracetam boosts brain health and function in several ways, primarily improving memory and enhancing high-affinity choline uptake (HACU).

Pramiracetam can help counter the effects of age-related cognitive decline by increasing acetylcholine synthesis and cerebral circulation.

Pramiracetam dosage recommendations are 250-400 mg up to three times a day, taken with a quality fat and, for best results, a supplemental choline source.

Hot Tags: pramiracetam, China pramiracetam manufacturers, suppliers, factory, 17 Methlytestosterone Powder, Letrozole Raw Powder, Oxymetholone Raw Powder, PEG MGF 2mg, Anadrol, GW501516