Clomiphene Citrate（Clomid） CAS: 50-41-9

Clomiphene triggers the brain's pituitary gland to secrete an increased amount of follicle stimulating hormone (FSH) and LH (luteinizing hormone). This action stimulates the growth of the ovarian follicle and thus initiates ovulation.

During a normal menstrual cycle only one egg is ovulated. The use of clomiphene often causes the ovaries to produce two or three eggs per cycle. Clomiphene is taken orally for 5 days and is active only during the month it is taken.

Clomid (Clomiphene Citrate) is a powerfully effective anti-estrogen officially classified as a Selective Estrogen Receptor Modulator (SERM).

Product Name: Clomid

Synonyms: Clomiphene Citrate; Clomiphene

CAS: 50-41-9

MF: C32H36ClNO8

MW: 598.08

EINECS: 200-035-3

Product Categories: SERMs

Properties

 

Melting point: 116.5-118°C

storage temp.: 2-8°C

Solubility: Slightly soluble in water, sparingly soluble in ethanol (96 per cent).

Water Solubility: Slightly soluble in water, methanol, chloroform (slightly), and DMSO (10 mM). Insoluble in ether.

Color: White to Off-White Powder

Clomiphene used in conjunction with a medication called Provera may be effective in initiating menstruation and ovulation in women who have no menstrual cycle:

• Treatment begins with a 5-7 day course of Provera, taken orally.
• Two to three days after Provera is completed, a menstrual period should begin.
• On the 3rd, 4th or 5th day of menstrual flow, a course of clomiphene is started.
• A clomiphene citrate 50 mg tablet is taken orally for 5 days.
• On day 11 or 12 of the menstrual cycle, ultrasound monitoring is conducted to determine if an ovarian follicle or follicles have developed. Also at this time, patients are asked to use an ovulation predictor kit to test their urine for a surge in LH (luteinizing hormone) indicating that eggs have matured and ovulation is imminent. If no LH surge is detected, ovulation itself may be triggered with an injection of the medication hCG (Ovidrel), which will cause the release of the mature egg(s) from the follicle(s).
• Natural intercourse or insemination is timed to ovulation.
• If ovulation has been assisted by an hCG injection, a form of the hormone progesterone is given via vaginal tablets or gel. The progesterone hormone serves to support the endometrial (uterine) lining and prepare it for the fertilized egg.
• Two weeks after ovulation, patients are asked to take a home pregnancy (urine) test. If the test is positive, a blood test will be performed to confirm results.

If ovulation doesn't occur during this initial clomiphene dosage, another course of provera will be prescribed and the dose of clomiphene increased until ovulation occurs. It may be possible to begin another clomiphene cycle immediately or, if residual cysts are present on the ovarian follicles, a 'rest' cycle may be advised before resuming treatment.

If ovulation cannot be induced even with a higher dose of clomiphene, this form of treatment will be discontinued, and ovulation induction may be attempted again using a different form of fertility drug (letrozole or gonadotropins).

Clomid, or Clomiphene Citrate, is a SERM (selective estrogen receptor modulator), so it's in the same grouping as tamoxifen (nolvadex). It is the most widely prescribed drug for ovulation induction, which is useful for those who are infertile.

Male bodybuilders who cycle anabolic androgenic steroids (AAS) have found that the same mechanisms of increased LH (luteinizing hormone) can be taken advantage of to increase total testosterone levels. This is why clomid is popular in post cycle therapy (PCT) among those who cycle anabolic steroids. Since clomid has ability to bind to the estrogen receptors, much like nolvadex, in male users who run estrogenic compounds such as testosterone, dianabol, and deca durabolin, it can be used as gynecomastia treatment (anti-gyno). However, clomid is a fairly weak anti-gyno aid, and is rarely used for that purpose. Due to its ability to boost testosterone levels, it has been put on the WADA (world anti-doping agency) list of illegal doping agents in sport.

When a steroid user runs a cycle their HPTA becomes suppressed; as a result, their bodies LH and FSH drop to almost zero (0) and their body stops producing testosterone. Their testicles typically will shrink as the body realizes there are too many hormones present and it's not necessary to produce more. So, when you come off a cycle it's important to run a PCT (post cycle therapy) to help recover the body's HPTA.

Clomid stimulates the hypophysis to release more gonadotropins. Gonadotropins are protein hormones that are secreted by gonadotrope cells of the pituitary gland and stimulate faster and higher release of follicle stimulating hormone (FSH) and luteinizing hormone (LH). When an increase in gonadotropins happens, the rise in LH will spike up the total testosterone levels allowing the user to artificially maintain high testosterone levels until their own body is able to recover, thus maintaining gains.

If you're going to put it into your body from medicine to hormones or in this case a SERM you are going to want to know the proper dose; after all, without this information it's unlikely you're going to be able to use it correctly. Like many things a Clomid dosage can vary quite dramatically but one thing is for certain the average Clomid dosage among many performance enhancers is far too low. It is very common to see a Clomid dosage of 50mg per day for Post Cycle therapy (PCT) purposes and while there is a use for this dose during PCT it should be noted, 50mg of this SERM is about the equivalent of 10mg of Nolvadex.

Clomiphene comes as a 50mg tablet and is taken orally.

It is typically taken once a day for five days, with the first tablet taken on about the fifth day of the menstrual cycle. Women who don't have menstrual cycles can start the medication at any time.

Clomiphene should be taken exactly as directed, and dosages should not be adjusted unless under the guidance of a healthcare provider.

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