Arimidex Powder Product details
Product Name: Arimidex powder
Other Name: Anastrozole Powder
CAS No: 120511-73-1
MF: C17H19N5
MW: 293.37
Appearance: white powder.
Purity: 99%
Arimidex Powder

Product Description
Arimidex powder is a prescription medicine used to treat the symptoms of breast cancer in postmenopausal women. Arimidex may be used alone or with other medications. Arimidex powder belongs to a class of drugs called Antineoplastics, Aromatase Inhibitor.
Applications
Arimidex powder is widely used in the pharmaceutical industry, mainly in the formulation of drugs for the treatment of breast cancer. Its function as an aromatase inhibitor makes it indispensable in hormone therapy regimens aimed at suppressing estrogen-induced tumor growth. In addition, anastrozole can be used in research settings to investigate new treatment modalities for hormone-sensitive malignancies.
Anastrozole's versatility extends beyond oncology, and emerging research is exploring its potential therapeutic benefits in other hormone-related conditions, such as endometriosis and male hypogonadism. Its selective action on estrogen synthesis positions it as a valuable tool in the treatment of several hormonal disorders.
COA
|
Items |
Standard |
Results |
|
Description |
White crystalline powder |
Complies |
|
Identification |
IR HPLC Reactive |
Conform with standard IR Conform with standard HPLC Conform |
|
Solubility |
Freely soluble in methanol, acetone, ethanol and tetrahydrofuran. And very soluble in acetonitrile |
Complies |
|
Total Impurity |
max.0.5% |
0.18% |
|
Total Unspecified Impurity |
max. 0.2% |
0.08% |
|
Individual unspecified impurlty |
max. 0.1% |
0.05% |
|
Related compound B |
max. 0.2% |
0.07% |
|
Related compound C |
max. 0.2% |
0.04% |
|
Related compound D |
max. 0.1% |
0.05% |
|
Related compound E |
max. 0.1% |
0.06% |
|
Limit of cyclohexane |
max. 0.08% |
ND |
|
Limit of ethylacetate |
max. 0.1% |
0.07% |
|
Melting point |
81.0~84.0¡æ |
82.5~83.2℃ |
|
Water |
max. 0.3% |
0.21% |
|
Residue on ignition |
max. 0.1% |
0.07% |
|
Heavy Metals |
max.0.001% |
Complies |
|
Assay (HPLC) |
98.0%~102.0% |
99.80% |
|
Storage |
Cool and dry |
|
|
Conclusion |
It complies to USP32 . |
|
Usage:
An aromatase inhibitor. Used as an antineoplastic raw material. Potent selective triazole aromatase inhibitors can inhibit the cytochrome P-450 aromatase enzyme, which depends on estrogen blockade and estrogen biosynthesis to stimulate breast cancer cell growth factors. Treatment of breast cancer, especially for those with hormonal relapse after adjuvant therapy after menopause for women with advanced breast cancer.
What does Arimidex powder do to the body?
Estrogen is a hormone that plays a key role in the growth and development of breast cancer. It is produced in the body by an enzyme called aromatase, which converts androgens (male hormones) into estrogen. By blocking the activity of aromatase, Arimidex reduces the amount of estrogen in the body, which can slow or stop the growth of breast cancer cells.
In addition to its use in breast cancer treatment, Arimidex has also been used off-label to treat infertility in women with ovulatory disorders. In these cases, Arimidex powder can help to stimulate ovulation by reducing the levels of estrogen in the body, which can interfere with the normal hormonal balance required for ovulation.
The use of Arimidex powder can have several effects on the body, some of which are beneficial and some of which can be potentially harmful.
Some of the most notable effects of Arimidex powder include:
● Reduced risk of breast cancer recurrence: Arimidex powder has been shown to be effective in reducing the risk of breast cancer recurrence in postmenopausal women with hormone receptor-positive breast cancer. In clinical trials, Arimidex has been shown to be more effective than tamoxifen, another commonly used breast cancer drug, in reducing the risk of recurrence.
● Bone loss: One of the potential side effects of Arimidex powder is bone loss, which can increase the risk of osteoporosis and bone fractures. Estrogen plays an important role in maintaining bone density, and by reducing estrogen levels, Arimidex can accelerate bone loss. To minimize the risk of bone loss, women taking Arimidex powder may be advised to take calcium and vitamin D supplements, as well as engage in weight-bearing exercise.
● Hot flashes: Arimidex powder can cause hot flashes and other menopausal symptoms, such as vaginal dryness and mood changes. These symptoms are caused by the reduction in estrogen levels and can be managed with lifestyle changes, such as dressing in layers and avoiding triggers like caffeine and alcohol, as well as medications like antidepressants and hormone replacement therapy.
● Cardiovascular effects: Arimidex powder may have a beneficial effect on cardiovascular health by reducing the risk of heart disease and stroke. Estrogen has a protective effect on the cardiovascular system, and by reducing estrogen levels, Arimidex may increase the risk of these conditions. However, studies have shown that Arimidex powder may have a neutral or even beneficial effect on cardiovascular health, particularly in women who are at high risk for these conditions.
● Joint pain: Arimidex powder can cause joint pain and stiffness, particularly in the hands and wrists. This side effect is thought to be caused by the reduction in estrogen levels, which can affect the production of collagen in the joints. To manage joint pain, women taking Arimidex powder may be advised to engage in gentle exercises, such as yoga or swimming, and may be prescribed pain medications or anti-inflammatory drugs.
In conclusion, Arimidex powder is a medication that is primarily used to treat breast cancer in postmenopausal women. It works by blocking the production of estrogen in the body, which can slow or stop the growth of breast cancer cells.
Arimidex powder Dosage
The dose of Arimidex powder is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Arimidex should be continued until tumor progression. Arimidex powder can be taken with or without food.
For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, ARIMIDEX was administered for five years.
No dosage adjustment is necessary for patients with renal impairment or for elderly patients.
How to store Anastrozole(Arimidex) powder?
Do not store above 30°C.
Keep Arimidex powder out of the sight and reach of children. Keep in a safe place where children cannot see or reach.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
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