Ivermectin

Ivermectin Basic Information

 

Product Name: Ivermectin

CAS: 70288-86-7

MF: C48H74O14

MW: 875.09

EINECS: 274-536-0

Appearance: White Powder

Ivermectin also called Ivomec, is a kind of medicine that has a good effect on mite disease treatment.It will cause poisoning if were overcommit ted. The symptoms of ivermectin poisoning are as follows: vomiting, accelerated breathing, weakness and paralysis in arms and legs, and congestive heart failure that would cause death.

Rescue: Just take orally mung bean licorice drink detoxification with 10% of glucose and inject dexamethasone when necessary.

Ivermectin is white or light yellow crystalline powder and soluble in methyl alcohol, ester and aromatic hydrocarbon but water. Ivermectin is a kind of antibiotic medicine which has a driving and killing effect on nematodes, insects and mites. Injection and troche which are made from ivermectin are mainly used in the treatments of livestock's gastrointestinal nematode, bovine hypodermosis, calf fly maggot, sheep nasal fly maggot, and scabies of sheep and pigs. Besides, ivermectin can also be available for the treatment of plant-parasitic nematodes (ascarid, lungworm) in poultry. In addition, it can also be made into agricultural insecticide to kill mite, plutella xylostella, cabbage caterpillar, leaf miner, phylloxera and nematode which are widely parasitic in plants. The most outstanding feature of this insecticide is that it has little side effects and can drive and kill many kinds of parasites both internally and externally at a time.

Ivermectin is a kind of botanical pesticide which is made of cynanchum komarovii, sophora alopecuroides and many other plants and Chinese herbal pieces through grinding, dissolving, adding promoters and penetrant and processing the mixtures. Its action mechanism is mainly based on contact poisoning with stomach toxicity as an complementary, which has a promoting effect on plant growth. It can be used to prevent and kill all kinds of aphids and defoliators. If diluted with water to 1000～2000 times and spayed, its control effect can reach above 98%. Ivermectin is a new generation of botanical pesticide that is low toxicity, low residual and has no hazard to people, livestock and environment.

The insecticidal mechanism of ivermectin is to inhibit the synthesis of chitin of insect epicutile. The main component of chlorbenzuron is stomach poison, but it can also intrude into insect epicutile and take effect. The prevention and treatment of defoliator has many advantages such as special action mechanism, good effect, long residual period, low cost, tolerant to rain shower, not easy to generate insecticide resistance and safe for plants, human, livestock and environment.

1. Ivermectin is available for controlling and treating onchocerca volvulus, and its untoward effect is lower than that of carbamazine.
2. Ivermectin can be used as a kind of antiphrastic drug and has an anthelmintic activity towards nematode, hookworm, roundworm, worm, insect and mite.

Two mechanisms of action are thought to be involved in the action of IVM. The first is an indirect action in which motility of microfalaria is reduced, which in turn allows cytotoxic cells of the host to adhere to the parasite, resulting in elimination from the host. This action may occur by virtue of the ability of IVM to act either as a γ-aminobutyric acid (GABA) agonist or as an inducer of chloride ion influx, leading to hyperpolarization and muscle paralysis. The chloride ion influx appears to be the more plausible mechanism. Recently, it has been shown that IVM binds irreversibly to the glutamate-gated chloride channel of the nematode Haemonchus contortus, whereas the channel is in an open conformation. The binding then remains locked in the open conformation, allowing ions to cross the membrane, leading to the paralytic action of IVM. The result of this action is a rapid decrease in microfilarial concentrations.

A second action of IVM leads to the degeneration of microfilariae in utero. This action would result in fewer microfilariae being released from the female worms, and it occurs over a longer period of time. The presence of degenerated microfilariae in utero prevents further fertilization and production of microfilariae.

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