Nefiracetam

Product Name: Nefiracetam

CAS: 77191-36-7

MF: C14H18N2O2

MW: 246.3

EINECS: 636-080-4

Category: Nootropic

Nefiracetam Chemical Properties

 

Melting point: 151-155°C

Boiling point: 458.5±33.0 °C(Predicted)

Density: 1.187±0.06 g/cm3(Predicted)

storage temp.: Sealed in dry, Room Temperature

Solubility: DMSO: >5mg/mL

Appearance: white to off-white solid powder

Nefiracetam is a fat-soluble nootropic in the racetam-class of compounds. Nefiracetam is considered more potent than the original racetam, Piracetam.

It is similar in structure to Piracetam with a phenyl group and two methyl groups added to the amine of Piracetam. Nefiracetam, like all racetam nootropics, has a pyrrolidone nucleus at its core.

The structure of Nefiracetam is similar to Aniracetam.

Nefiracetam is used as a prescription drug in Japan. And as a supplement in the United States. Relatively new to the nootropics community. Neurohackers use Nefiracetam to boost learning, cognition and memory.

Nefiracetam helps:

• Neuroprotection: Nefiracetam helps control NMDA signaling which protects against excessive glutamate levels. Glutamate is powerful excitatory neurotransmitter. Too much glutamatedamages neurons and the entire brain.
• Neurotransmitters: Nefiracetam modulates GABA levels in the brain. Reducing GABA when it's too high, and increasing GABA levels if they're too low. Producing a calm-like focus and reducing anxiety. Nefiracetam prolongs the opening of calcium channels. Keeping neurotransmitters active longer. Improving memory formation and recall.
• Acetylcholine: Nefiracetam potentiates nicotinic acetylcholine receptors. Boosting the release of GABA and glutamate. Producing a calming effect while improving neuroplasticity and boosting learning and memory.

• Nefiracetam is fat-soluble while Piracetam is water-soluble. Fat-soluble molecules cross the blood-brain barrier more easily than water-soluble molecules.
• Both Nefiracetam and Piracetam are cognitive enhancers. And both have neuroprotective qualities. Both racetams are able to improve learning and memory. And both are able to prevent brain damage.
• Nefiracetam has additional benefits not shared with Piracetam. Nefiracetam can reduce anxiety and depression. And exhibits several other memory enhancing qualities over Piracetam.
• Nefiracetam increases the amount of time calcium channels in neurons remain open. Tied to protein kinase A (PKA) and the Gi alpha subunit (Gi/o protein), signaling is enhanced in the neuroreceptor independent of the synapse. This calcium channel pathway is critical for long-term potentiation (LTP) and the formation of long-term memories.
• Nefiracetam also potentiates protein kinase C alpha (PKCα) which is involved in long-term potentiation (LTP). PKCα is dependent on glutamate signaling.
• And Nefiracetam activates Ca2+/calmodulin-dependent protein kinase II (CaMKII) which is critical in memory formation. Again dependent on glutamate signaling.
• Finally, Nefiracetam potentiates acetylcholine receptors in the hippocampus which encourages glutamate release and LTP. Piracetam does not share this memory enhancing quality.

The bottom-line is Nefiracetam seems to be a much more potent memory enhancer that the original nootropic Piracetam.

Nefiracetam modulates GABA (gamma aminobutyric acid) in your brain. GABA is the primary inhibitory neurotransmitter in the brain. Its role is to keep glutamate, the primary excitatory neurotransmitter from overwhelming your brain. And causing damage.

When GABA levels are too low, you experience anxiety, insomnia, poor mood and restlessness. Left unchecked it can lead to neurodegenerative disease and a very poor quality of life.

But when GABA is too high, you have a toxic environment in your brain. Causing damage to neurons and other areas of your brain. Nefiracetam modulates GABA levels, keeping them steady for a healthy brain. And improved long-term memory.

Nefiracetam contributes to learning by enhancing long-term potentiation (LTP). Enhancing NMDA-dependent LTP at low concentrations and AMPA dependent LTP at higher concentrations.

Nefiracetam combined with choline boosts the production of the crucial neurotransmitter acetylcholine. Improving memory, recall and focus.

Nefiracetam is fat-soluble and quickly enters your brain after you take it. Once in your brain, it boosts signal transmission, and protects neurons.

Nefiracetam boosts acetylcholine so you should take it with a good choline source. Try Alpha GPC or CDP-Choline with Nefiracetam. And give your brain the choline it needs.

Supplementation of nefiracetam appears to be in the 150-450mg range over the course of a day (usually divided into three even doses). Animal studies using acute doses tend to note most benefits in the 3-10mg/kg range, and this correlates to a human dose of 0.48-1.6mg/kg (for a 150lb person, 33-110mg) which is similar to the aforementioned human doses.

Although single doses of nefiracetam do not appear to promote cognition, it is able to affect the brain within 30-60 minutes following oral ingestion. It is not certain whether nefiracetam needs to be taken prior to cognitive training.

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