Lidocaine Hydrochloride Basic Information

Product Name: Lidocaine hydrochloride

Synonyms: Lidocaine Hcl

CAS: 73-78-9

MF: C14H23ClN2O

MW: 270.8

EINECS: 200-803-8

Melting point: 80-82°C

Storage temp.: Inert atmosphere, 2-8°C

Water Solubility: Water : ≥ 36 mg/mL (132.94 mM)

Chemical Properties: White to Off-White Solid

Lidocaine hydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) and has antiproliferative effect on human tongue cancer cells. Lidocaine hydrochloride is a local anesthetic and cardiac depressant used as an antiarrhythmia agent.

Description

Lidocaine hydrochloride,2-(diethylamino)-2 ,6 -acetoxylidide monohydrochloride(Xylocaine), was conceived as a derivative of gramine(3-dimethylaminomethylindole) and introduced as a localanesthetic. It is now being used intravenously as a standardparenteral agent for suppression of arrhythmias associatedwith acute myocardial infarction and cardiac surgery.It isthe drug of choice for the parenteral treatment of prematureventricular contractions.

Indications

The drug can be used for infiltration anesthesia, epidural anesthesia, surface anesthesia and nerve conduction block.

The drug can be used for acute myocardial infarction after ventricular premature beats and ventricular tachycardia, and for digitalis poisoning, cardiac surgery and ventricular arrhythmias caused by cardiac catheterization. But it is usually ineffective for supraventricular arrhythmias.

Usage and dosage

Surface anesthesia with solution of 2% to 5%.Infiltration anesthesia with solution of 0.25% to 0.5%, conduction anesthesia with 2%, each injection point, horse, cattle 8 to 12 ml, sheep 3 to 4 ml. Epidural anesthesia with 2% solution, horse, cow, 8 to 12 ml, dog, cat, 0.22 ml per kilogram of body weight. Subcutaneous injection with 2% solution, pig, sheep, 80 ml, horse, cow, 400 ml, dog,25 ml, cat, 8.5 ml.

Treatment of arrhythmia, intravenous injection: Per kg of dog's body weight of the initial dose is 2 to 4 mg, followed by 25 to 75 micrograms per minute intravenous infusion; Cat initial dose of 250 to 500 micrograms, followed by intravenous infusion of 20 micrograms per minute.

Adverse effect

The incidence of adverse effect with lidocaine hydrochloride was about 6.3%. Most adverse effects are dose dependent. Adverse effects are drowsiness, dizziness, nausea, vomiting, burnout, euphoria, insanity, muscle convulsions, syncope, blurred vision, confusion and difficulty breathing. Large doses lead to severe sinus bradycardia, cardiac arrest, severe atrioventricular block and weakened myocardial contractility, reduced blood pressure and so on. Excess concentrations of lidocaine hydrochloride in the blood cause some problems. For example, atrial conduction slows, atrioventricular blocks (A-V-B), and inhibits myocardial contractility and cardiac output decreases. There are little allergic effects, such as erythema rash, angioneurotic edema and so on.

Frequent asked question for Lidocaine Hcl

Q: What is lidocaine hydrochloride powder used for?

A: Lidocaine Hydrochloride Monohydrate powder intradermal injection system is indicated for use on intact skin to provide topical local analgesia prior to venipuncture or peripheral intravenous cannulation, in children 3–18 years of age.

Q: Is lidocaine and lidocaine hydrochloride the same?

A: Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+.

Q: Why is lidocaine hydrochloride used more than lidocaine?

A: Lidocaine Hydrochloride USP Monohydrate binds more readily to sodium channels in an activated state; thus, it tends to take effect faster in rapidly firing neurons.

Q: What is stronger benzocaine or lidocaine?

A: Lidocaine is a stronger, yet equally effective, local anesthetic than Benzocaine and its effects last for approximately 90 minutes. Benzocaine is considered to be less severe in nature and its effects last for around ten minutes from the time of application.

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