Tetracaine hydrochloride Basic Informaation

Product Name: Tetracaine hydrochloride

Synonyms: Tetracaine Hcl

CAS: 136-47-0

MF: C15H25ClN2O2

MW: 300.82

Product Categories: Local anesthetic

Tetracaine hydrochloride Chemical Properties

Melting point: 149°C

Density: 1.1279 (rough estimate)

refractive index: 1.5200 (estimate)

Storage temp.: 2-8°C

Solubility: alcohol: solublesoluble 40 parts of solvent

Appearance: White to Almost white Powder

Water Solubility: Soluble in water at 50mg/ml

Tetracaine is a local anaesthetic agent used to induce local analgesia in the eyes and skin during medical procedures.

Tetracaine hydrochloride description

Tetracaine hydrochloride is a local anesthetic drug and an ester derivative of p-amino benzoic acid. It acts by interfering with the entry of sodium ions into nerve cells and is one of the commonly used topical anesthetics. It is a highly effective local anesthetic that reversibly blocks nerve function. It is clinically used for infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, its local anesthesia effect is remarkable. Tetracaine hydrochloride has been widely used in clinical practice.

Tetracaine hydrochloride Application

Identify the mechanism of action of tetracaine.
Summarize the indications for using tetracaine as an anesthetic agent.
Review any potential adverse events associated with tetracaine.
Explain the importance of improving care coordination among the interprofessional team to enhance the delivery of care for patients who can benefit from tetracaine anesthesia.

Tetracaine hydrochloride Dosage

Dosing for some common indications for the ophthalmic formulation (as the most common use) include the following:

Corneal foreign body removal: 1 to 2 drops in the affected eye every 5 to 10 minutes for 1 to 3 doses. This regimen can also be used for suture removal.
Brief ophthalmic anesthesia (tonometry or short corneal/conjunctival procedures): 1 to 2 drops in the eye(s) prior to starting the procedure.
Prolonged ophthalmic anesthesia (e.g., cataract extraction or other extended procedures): 1 to 2 drops in the affected eye(s) every 5 to 10 minutes for 3 to 5 doses.

For local dermal anesthesia, tetracaine is also available in a topical cream combined with lidocaine. It is applied to intact skin from 20 to 60 minutes in advance of superficial dermal procedures.

Tetracaine hydrochloride Adverse reaction

The following serious ocular adverse reactions are described elsewhere in the labeling:

Corneal injury with Intracameral Use
Corneal Toxicity
Corneal Injury due to Insensitivity

The following adverse reactions have been identified following use of Tetracaine Hydrochloride Ophthalmic Solution 0.5%. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Ocular Adverse Reactions

Transient stinging, burning, and conjunctival redness, eye irritation, eye pain, ocular discomfort.

Frequently asked questions for Tetracaine hydrochloride

Q: What is the difference between lidocaine and tetracaine?

A: Lidocaine is an amide-like anesthetic such as prilocaine, etidocaine, and bupivacaine. Tetracaine is an ester-like anesthetic like procaine and benzocaine. All local anesthetics are lipophilic and soluble in water.

Q: Is tetracaine stronger than lidocaine?

A: Tetracaine was found to be better than lidocaine only if augmented by either increasing the concentration to 1% (solution) or by increasing the penetration by adding benzalkonium chloride (gel).

Q: What strength is tetracaine topical?

A: Available in 2%, 4%, 6% Strengths
Tetracaine is used for surface anesthesia of the nose and throat, and to eliminate laryngeal and esophageal reflexes prior to bronchoscopy, bronchography, esophagoscopy, and more. The anesthetic effect takes about 5 to 10 minutes to occur.

Q: Is tetracaine hydrochloride toxic?

A: May cause severe internal injury. Skin contact May cause skin sensitisation or allergic reactions in sensitive individuals. Prolonged contact may cause dryness of the skin.

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