Procaine Hydrochloride Basic Information

Product Name: Procaine hydrochloride

Synonyms: Procaine Hcl

CAS: 51-05-8

MF: C13H21ClN2O2

MW: 272.77

EINECS: 200-077-2

Procaine hydrochloride Chemical Properties

Melting point: 155-156 °C(lit.)

Boiling point: 195-196°C 17mm

Density: 1.1761 (rough estimate)

Refractive index: 1.5270 (estimate)

Fp: 195-196°C/17mm

Storage temp.: 2-8°C

Description

Procaine hydrochloride, synthetic organic compound used in medicine as a local anesthetic. Generally used in a 1 to 10 percent saline solution, procaine hydrochloride is administered by injection for infiltration (area flooding as in dental anesthesia), nerve-block, spinal, and caudal anesthesia. Unlike cocaine, procaine is not toxic, addicting, or irritating. It has been displaced somewhat by the chemically related drugs lidocaine and mepivacaine, which produce prompter, more intense anesthesia.

Be careful not to confuse the procaine used by mouth with the prescription procaine given by injection only under the supervision of a healthcare professional.

Procaine is most often used as an anti-aging agent for conditions such as dementia, age-related decline in memory and thinking skills, quality of life, and many others, but there is no good scientific evidence to support these uses.

Effective for

Pain reduction during surgery. Procaine injection is an FDA-approved prescription product used as a local anesthetic.

Insufficient Evidence for

Decline in memory and thinking skills that occurs normally with age. Early research shows that taking procaine by mouth or as a shot doesn't improve most measures of memory and thinking skills in older people. Also, it might cause side effects.
Diseases, such as Alzheimer disease, that interfere with thinking (dementia). Early research shows that procaine doesn't improve thinking skills in people with dementia.
Arthritis.
"Hardening of the arteries" in the brain (cerebral atherosclerosis).
Depression.
Hair loss.
High blood pressure.
Sexual problems.
Other conditions.
More evidence is needed to rate the effectiveness of procaine for these uses.

Frequent Asked Questions for Procaine?

Q: What is procaine hydrochloride used for?

A: Procaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic.

Q: What is the effect of procaine?

A: What is procaine? Procaine is a local anesthetic. Procaine causes loss of feeling (numbness) of skin and mucous membranes. Procaine is used as an injection during surgery and other medical and dental procedures.

Q: Is procaine stronger than lidocaine?

A: Procaine is the oldest aminoester local anesthetic in clinical use. It is a derivative of PABA, with a relatively high pKa and low lipid solubility, which gives it a slow onset and a short duration of action. This reduces its usefulness when compared with other short-acting local anesthetics, such as lidocaine.

Q: What is the duration of action of procaine hydrochloride?

A: Procaine provides a relatively brief period of anesthesia (45 to 60 minutes), which may be prolonged by addition of a vasoconstrictor.

Q: What is the difference between procaine and procaine hydrochloride?

A: Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses.

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