Procaine Base

Product details

 

Product name: Procaine Base

CAS No.: 59-46-1

Molecular formula: C13H20N2O1

Molecular weight: 236.31

EINECS number: 200-426-9

Melting point: 61C(Predicted)

Storage condition: Room Temperature or 2-8C

Purity: >99%

Standard: Pharmaceutical Grade

Appearance: White or almost white crystal powder

Procaine Base is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Procaine has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Procaine is an ester anesthetic. It is metabolized in the plasma by the enzyme pseudocholinesterase through hydrolysis into para-aminobenzoic acid , which is then excreted by the kidneys into the urine.

Procaine Base powder can be used as a raw material, chemical material in the laboratory. These physical properties help characterize its purity and solid-state structure. The electrical charge is neutral, so it does not have the advantages of electrostatic force and repulsive force. This limits its potential in technological applications. It is a chiral compound with both left-handed and right-handed properties. This optical activity is due to the chiral center in its molecule. The rotation of left rotation is -14.3 °, and the rotation of right rotation is+13.9 °. It has low toxicity. When used at the correct dosage, it is usually a safe anesthetic. However, excessive or misuse can lead to toxic reactions, including death. Overall, as an anesthetic drug, the study of its physical properties is crucial for its application and production, and these characteristics will also play an important role in the fields of technology and medicine.

Procaine Base is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.

Procaine Base is used as an injection during surgery and other medical and dental procedures.

Procaine suggested for use in reversing aging in modern times, it could be used to combat arthritis, arteriosclerosis, senile skin changes and baldness. Procaine containing benzoic acid has beenshown to markedly improve the absorption of procaine by fats, thus quickening its absorption by the human body.

Procaine also increases the speed with which the nerves conduct impulses, and decreases the rate of excretion of the 17 kerosteroids, which usually increases with age.

Anti-aging benefits of Procaine Base include increased nerve velocities, improved sense of well-being and increased potential life span.

Procaine is commonly used in dentistry as a local anesthetic for procedures such as fillings and extractions. It is also used in veterinary medicine as a pain reliever for animals. Procaine HCl is used in a variety of medical procedures, including spinal anesthesia and as a local anesthetic for minor surgeries.

The Procaine-Base-Infusion (Procaine HCl / Procaine Base):

Proprietary name: Novocain

Classification: Local anesthetic

Availability: 1% (10 mg/ml)

Average reversal dose (IV): 1-5 ml

Maximum single dose: 1-5 ml

Maximum total dose: 5 ml

Procaine Base is a local anesthetic drug of the amino ester group, which acts through multiple targets.Target: OthersProcaine is a local anesthetic of the ester type that has a slow onset and a short duration of action.Procaine (0.01–100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM

Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest

Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale.

Procaine Base is not used topically because of itsinability to pass through lipid membranes and finds use as aninfiltration agent for cutaneous or mucous membranes, forshort procedures. Procaine is also used for peripheral nerveblock and as an epidural agent to diagnose pain syndromes.

Procaine Base is very fast metabolizeedin the plasma through cholinesterases and a pseudocholinesterase in the liver via hydrolysisby ester. The inside vitroelimination hall suspension time is approximately 60 seconds. Any ConditionThat reduces the cholinesterase concentration can be increationexposure to procaine and potential toxicity. The decreased enzyme activity can be found with genetic deficiency, limeisease, malignancy, malnutrition, kidney loss, burns, third trimester of pregnancy, and after cardiopulmonary bypasssurgery. The Esterhydrolysis produces PABA, compound response for the allergic reactions in common for the esterils. Procaine is not used topically because of itsinability to pass through lipid membranes and finds use as aninfiltration agent for skin or mucous membranes, aschars procedures. Procaine is also used for rand nerveblock and as an epidural agent to diagnose pain syndromes.

Procaine base and prokaine hydrochloride have low toxicity and fast and safe. It is suitable for local anesthesia and is used in eye, ear, nose and tooth for infiltration anesthesia, conduction anesthesia and closing therapy. This product is also used to produce Procaine penicillin.

Procaine's base is a white powder, the base powder is extremely thin, but the only feature is that the prokaine base is not soluble in water, it can be used as a solid product, such as cream, while hydrochloride Procaine powder is a bright white crystal, Procaine is very easy to dissolve and water. The video is well experienced and explained in detail.

Procaine Base is easily soluble in water and methanol, slightly soluble in ethanol and chloroform, but not in benzene or dichloromethane. The solubility of this drug in water is 1g and can be dissolved in 100mL of water.

The solubility is crucial in studying the chemical and physical properties of the substance. It is a weakly acidic drug with a pKa value of 8.9. The solubility in water is temperature dependent, and the higher the temperature, the higher its solubility. The water solubility is 1 g/mL at 20 ℃, but it is about 7 g/mL at 40 ℃, which can be described by a solubility curve.

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