Flibanserin Basic Information

Product Name: Flibanserin

Alias: Female Viagra

CAS NO.:167933-07-5

Molecular Formula: C20H21F3N4O

Molecular Weight: 390.40

Purity: 99%

Grade: Pharmaceutical Grade

Appearance: White to beige Powder

Flibanserin Chemical Properties

Density: 1.292±0.06 g/cm3(Predicted)

Storage temp.: 2-8°C

Solubility: DMSO: soluble10mg/mL, clear

Pka: 12.12±0.30 (Predicted)

What is Flibanserin?

Flibanserin is a prescription drug indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD), as characterized by low sexual desire that causes marked distress or interpersonal difficulty.

What is flibanserin used for?

Flibanserin affects the way the brain works by interfering with communication among the brain's nerves in areas of the brain that control sexual desire and other pleasurable sensations. Nerves communicate with each other by making and releasing chemicals called neurotransmitters. The neurotransmitters travel to other nearby nerves where they attach to receptors on nerves. The attachment of neurotransmitters either stimulates or inhibits the function of the nearby nerves. Flibanserin blocks several of the receptors on nerves including dopamine type 4, and serotonin type 2A, 2B and 2C receptors. It also stimulates serotonin type 1A. How these effects improve sexual desire in women is unknown. Scientists think that flibanserin may regulate areas of the brain that control sexual desire in premenopausal women with reduced sexual interest and desire.

What is the dosage for flibanserin?

Flibanserin is administered once daily by mouth at bedtime. It should be stopped after 8 weeks if there is no improvement in symptoms.

What is effect of Flibanserin?

The effectiveness of flibanserin was evaluated in three phase 3 clinical trials. Each of the three trials had two co-primary endpoints, one for satisfying sexual events (SSEs) and the other for sexual desire. Each of the 3 trials also had a secondary endpoint that measured distress related to sexual desire.

All three trials showed that flibanserin produced a statistically significant increase in the number of SSEs and reduced distress related to sexual desire.

The first two trials used an electronic diary to measure sexual desire, and did not find a statistically significant increase relative to women treated with a placebo. These two trials also measured sexual desire using the Female Sexual Function index (FSFI) as a secondary endpoint, and a statistically significant increase was observed using this latter measure. The FSFI was used as the co-primary endpoint for sexual desire in the third trial, and again showed a statistically significant increase.

Frequently Question and Answer

Q: How long does it take for flibanserin to work?

A: How long does Addyi take to work? The clinical trials data suggest that flibanserin can take up to four weeks to see results, and up to eight or twelve weeks to see maximum results.

Q: What happens after taking flibanserin?

A: Flibanserin may cause CNS depression with somnolence and sedation. Fatigue, insomnia, and dry mouth can also occur. Patients should not drive or engage in other activities requiring full alertness until at least 6 h after taking flibanserin.

Q: How long does it take for flibanserin to work?

A: How long does flibanserin take to work? The clinical trials data suggest that flibanserin can take up to four weeks to see results, and up to eight or twelve weeks to see maximum results.

Q: What are the disadvantages of flibanserin?

A: Side Effects
1.Blurred vision.
2.Dizziness, fainting, or lightheadedness, especially when getting up suddenly from a lying or sitting position.
3.Sleepiness or unusual drowsiness.
4.Unusual tiredness or weakness.

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