NSI-189

Basic Info

 

Product Name: NSI-189

CAS No.: 1270138-40-3

MF: C22H30N4O

MW: 366.4998

Appearance and shape: Off-white powder

Typical use: Nootropics

NSI-189 is an experimental neurogenic compound that may potentially treat MDD, traumatic brain injury, stroke, cognition problems, mental disorders, post-traumatic stress disorder, and neurodegenerative disease due to aging.

Neuralstem Inc is a biopharmaceutical company that develops NSI-189. The chemical is being investigated as an alternative drug designed for patients who failed to respond to conventional medications.

In 2011, 41 volunteers completed the phase I clinical trials. Following this was the phase IB trial in 2012 and 2014, which focused on treating patients with MDD.

However, the phase II clinical trial was not as successful as phase I. It failed to meet the requirements for the primary effectiveness endpoint in MDD [R].

At present, NSI189 is still being tested for other conditions such as improved brain health, diabetic neuropathy, stroke, neurodegenerative disease, post-traumatic stress disorder, and Angelman syndrome. It is used to treat traumatic brain injury.

The FDA has granted NSI-189 Orphan Drug Designation as a treatment for the rare disease, Angelman syndrome.

1. Enhance cognition and memory formation NSI-189 phosphate powder

2. Anxiolytic properties NSI-189 phosphate powder

3. Anti-depressive effect NSI-189 phosphate powder

4. Treatment of Alzheimer's and Parkinson's disease NSI-189 phosphate powder

5. Increase coordination NSI-189 phosphate powder

6. Improves mood NSI-189 phosphate powder

7. Help fight fatigue NSI-189 phosphate powder

8. Prevent oxidation within the brain NSI-189 phosphate powder

9. Treat alcohol related brain damage NSI-189 phosphate powder.

Works extremely well as an antidepressant

Has procognitive benefits

Improves memory and learning

Stimulates neurogenesis (growth of new brain cells)

NSI-189 phosphate powder is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine . NSI-189 powder has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo. The hippocampus is responsible for the consolidation of information from short-term memory to long-term memory, along with spatial navigation . nootropics neurogenic drugs nsi-189 powder.

Due to the fact that NSI-189 phosphate powder is still a trial drug, there has not yet been a fixed dosage. However, during the trials patients were given daily doses of 40mg, 80mg, and 120mg at the highest dose per day over the course of 28 days. During this period, patients did not report any serious events or side effects, and the NSI-189 phosphate was found to be well tolerated. Also, there was a significant reduction in depression and cognitive symptoms for patients taking the lower doses of 40mg and 80mg, but not for those taking 120mg per day. The preliminary findings of the trials are supportive of the idea that NSI-189 phosphate can treat MDD. Nonetheless, further studies on the dosage and the method of action of NSI-189 phosphate are imperative to help confirm preliminary observations and help draw conclusions.

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Side effects of NSI-189 phosphate powder (1270138-41-4):

Side effects reported have been dry mouth, palpitations, headaches, dizziness, sleepiness, fatigue, restlessness, poor quality of sleep, nightmares/vivid dreams, parathesia, insomnia, hyperthermia, nausea, skin pain, and rash.

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