PRL-8-53

Product Name: PRL-8-53

CAS: 51352-87-5

MF: C18H22ClNO2

MW: 319.82578

EINECS: 206-141-6

Form: Crystalline solid Powder

PRL-8-53 Chemical information

 

Application: PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine with memory-enhancing effects, used in neuroscience research related to memory enhancement and protection against memory impairment.

Appearance: White or off-white powder

Physical State: Solid

Solubility: Soluble to 25 mM in Ethanol, Soluble to 50 mM in Water.

Storage: Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.

Stability: Stable for at least two years when stored as above.

PRL-8-53 is a synthetic nootropic supplement, meaning it was created in a lab. Its full name is methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate.

Researchers found that oral supplementation of PRL-8-53 was able to improve avoidance learning in rats. One human study has also been done on PRL-8-53. Each participant ingested a placebo and PRL-8-53, at separate times, in a double blind crossover study. Participants then took a memory test, consisting of twelve monosyllabic words in a particular order. The test was conducted three times, immediately after supplementation, one day after supplementation, and four days after supplementation.

People that remembered more than eight words after taking a placebo experienced minor benefits, but people over 30 or with poor short term memory benefitted greatly from supplementation. In some cases, their score on the word test doubled.

No side effects were observed in the human study, and preliminary rodent evidence suggests PRL-8-53 is safe. Using PRL-8-53 as a dietary supplement, however, cannot be recommended at this time because it is a synthetic substance and all of the evidence for its effects comes from studies funded by the holder of the patent. Though this link should not invalidate the available evidence, independent replication would go a long way toward confirming PRL-8-53's efficacy.

One of PRL-8-53's main benefits is its ability to boost dopamine and, in turn positively affect memory formation.

This is because elevated dopamine levels are linked to significant improvement in adaptive and working memory.

PRL-8-53's chemical constituents are major contributors to this benefit as well since it is produced by combining phenylethylamine and benzoic acid.

Phenylethylamine (PEA) is known for improving motor function in animals.

Animal studies show that phenylethylamine (from PRL-8-53) improves rats' avoidance learning and locomotor behavior.

The one human study on PRL-8-53 also confirms its potency as a memory enhancer as it demonstrated the ability to enhance learning and help in retaining verbal information.

While PRL-8-53 improves long-term memory and reduces cognitive decline. Its impact on short-term memory is not very clear.

More evidence is needed to determine the ideal dosage for PRL-8-53. The effective dosage may vary, since the only human study on PRL-8-53 used a single dose of 5mg, while patent information on PRL-8-53 suggests a dosage range of 0.01-4mg/kg, with an 'ideal' range of 0.05-1.2mg/kg.

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